大鼠骨量与骨生物力学特性之间的相关性  

Correlations between bone mechanical properties and bone mass in ratsCorrelations between bone mechanical properties and bone mass in rats

作　　者：伍贤平[1] 廖二元[1] 陆泽元[1] 宋先村[2] 黄干[1] 邓小戈[1] 

机构地区：[1]湖南医科大学附属二院代谢内分泌研究所,410011 [2]解放军国防科学技术大学航天技术系108室

出　　处：《中国骨质疏松杂志》1999年第3期1-4,共4页Chinese Journal of Osteoporosis

基　　金：国家九五攻关课题

摘　　要：目的　观察骨质疏松模型大鼠骨量与骨强度之间的关系。方法　采用扇形束双能 Ｘ 线吸收法（ Ｄ Ｘ Ａ）测量５０只 Ｓ Ｄ 大鼠全身、股骨和腰椎（ Ｌ４ Ｌ６）骨量（骨矿含量和密度）。采用三点弯曲试验测量股骨抗弯和压缩试验测量椎体（ Ｌ４）抗压力学特性。结果　鼠体重和鼠全身骨量及股骨骨量与股骨抗弯系数、弹性弯距和最大弯距呈显著正相关（ｒ＝ ０５５２～０８２６， Ｐ＜ ０００１）；鼠体重与股骨的弹性应力（ｒ＝－ ０３６０， Ｐ＜ ００５）和抗弯强度（ｒ＝ － ０３３８， Ｐ＜ ００５）呈显著负相关；腰椎骨矿密度与椎体弹性载（ｒ＝０３２５， Ｐ＜ ００５）和最大载（ｒ＝ ０３４０， Ｐ＜ ００５）呈显著正相关，与弹性应力、抗压强度和弹性模量相关无显著性（ｒ＝ ０１５３～０２７５， Ｐ＞ ００５）。结论　大鼠股骨和全身骨量与抗弯系数。Objective\ The relationship between bone mass(BMC and BMD) and bone strength was investigated in rat model of osteoporosis.Methods Bone mass in whole body,femur and lumbar spines(L4\|L6) was measured by dual energy X\|ray absorptiometry(DXA) in 50 SD rats.The bending mechanical property of femur was measured by three\|point bending test and the compression mechanical property of vertebra was measured by compression test. Results \ Significant correlations were found between body weight,bone mass of the whole body or femur and bend coefficient,elastic transverse distance or ultimate transverse distance of the femur ( r=0 552 to 0 826,P<0 001 ).There were significant negative correlations between elastic stress( r=-0 360,P<0 05 ) or bending strength ( r=-0 338,P<0 05 ) of the femur and body weight.The lumbar spines(L4\|L6) BMD correlated with elastic load ( r=0 325,P<0 05 ) or maximal load ( r=0 340,P>0 05 ),but not with elastic stress,bending strength or elastic modulus ( r=0 153 to 0 275,P<0 05 ) at the lumbar spine(L4). Conclusions\ There are highly significant correlations between bending coefficient,elastic transverse distance or ultimate transverse distance and bone mass of the femur or whole body in rats.\;

关 键 词：骨量 股骨 大鼠 全身 椎体 骨生物力学 相关性 骨矿密度 双能X线吸收法 骨矿含量 

分 类 号：R681[医药卫生—骨科学] R683[医药卫生—外科学]