补肾中药复方延缓老年雄性大鼠股骨皮质骨、松质骨骨量增龄性丢失的实验研究  

Effect of a compound ‘kidney tonifying’ Chinese herbal preparation on femur cortical and trabecular bone loss induced by aging in aged male rats

作　　者：张戈[1] 史万忠[1] 石印玉[1] 曹月龙[1] 秦红友 张倩[2] 宫斌[2] 莫启忠[2] 

机构地区：[1]上海市中医药研究院骨伤科研究所,200032 [2]上海中医药大学基础医学院中医基础实验室

出　　处：《中国骨质疏松杂志》1999年第3期51-54,共4页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金

摘　　要：目的　研究补肾中药复方延缓老年大鼠股骨皮质骨 、松质骨骨量增龄性丢失的作用。方法３６只２４月龄 Ｓ Ｄ 雄性大鼠随机分为２４月龄本底对照组、３０月龄增龄对照组、补肾中药复方低剂量组、补肾中药复方高剂量组，每组各９只。低剂量组、高剂量组均自２４月龄给药至３０月龄。各组相应处理以后分别测定各组大鼠左侧股骨以松质骨为主的近段、远段以及以皮质骨为主的中段的骨密度。结果　补肾中药复方低剂量组大鼠股骨各段骨密度增龄性减少率出现延缓的趋势；高剂量的补肾中药复方则能明显延缓股骨各段骨密度增龄性减少率。结论　补肾中药复方具有量效依赖性地延缓大鼠皮质骨。Objective\ To study quantitatively the effect of a compound ckidney tonifiying' Chinese herbal preparation(KTP) on femur cortical and trabecular bone loss induced by aging in aged male rats. Methods\ Thirty six male Sprague Dawley rats, 24 months old, were divided at random into four groups:Baseline control group (24 months old), aging control group (30 months old), high dose KTP group, and low dose KTP group, 9 rats each. The rats in high dose and low dose groups were given KTP for six months. Bone mineral density (BMD) in trabecular bone of proximal and distal segments of left femur and cortical bone of middle segment was measured after every group had received appropriate treatment. Results\ The decreases in BMD induced by aging in corresponding femur segment were slightly delayed in low dose KTP group and significantly delayed in high dose KTP group. Conclusions\ KTP can delay cortical and trabacular bone losses induced by aging in aged rat in a dose effect dependent manner.\;

关 键 词：补肾中药 复方 延缓 增龄性 股骨 松质骨 高剂量 骨皮质 骨密度 雄性大鼠 

分 类 号：R285[医药卫生—中药学] R681[医药卫生—中医学]