Approaches to post-testicular contraception  

作　　者：TrevorGCooper CHYeung 

机构地区：[1]Institute of Reprocuctive Medicine of the University, Munster, Germany,Institute of Reprocuctive Medicine of the University, Munster, Germany

出　　处：《Asian Journal of Andrology》1999年第1期29-36,共8页亚洲男性学杂志（英文版）

摘　　要：The induction of infertility in males of several species through epididymal interference is more difficult to achieveby reduction of the mounts of epididymal secretions (eg α-glucosidase, L-carnitine) or immunological interferencewith secreted proteins ( eg D/E, P34H, P26h) than by direct actions of drugs on sperm function (eg inhibition ofglyceraldehyde 3-phosphate dehydrogenase by chloro-compounds). The latter approach holds promise for mankind ashuman sperm are susceptible to glycolytic inhibition. Future contraceptive developments may arise from production oftargeted inhibitors, research on the displacement of sperm proteins in the epididymis and interference with sperm plasmamembrane ion channels.The induction of infertility in males of several species through epididymal interference is more difficult to achieveby reduction of the mounts of epididymal secretions (eg α-glucosidase, L-carnitine) or immunological interferencewith secreted proteins ( eg D/E, P34H, P26h) than by direct actions of drugs on sperm function (eg inhibition ofglyceraldehyde 3-phosphate dehydrogenase by chloro-compounds). The latter approach holds promise for mankind ashuman sperm are susceptible to glycolytic inhibition. Future contraceptive developments may arise from production oftargeted inhibitors, research on the displacement of sperm proteins in the epididymis and interference with sperm plasmamembrane ion channels.

关 键 词：EPIDIDYMIS CONTRACEPTION ANTIFERTILITY male infertility aniMal models 

分 类 号：R698.2[医药卫生—泌尿科学]