老年冠心病人的胆固醇水平对再发心脏事件的影响  

THE EFFECT OF THE LEVELS OF CHOLESTEROL ON RECURRENT HEART EVENT IN ELDERLY PATIENTS WITH CORONARY ARTERY DISEASE

作　　者：谢英[1] 张文[1] 胡旭东[1] 

机构地区：[1]首都医学院附属北京安贞医院老年心内科,100029

出　　处：《老年医学与保健》1996年第1期12-14,共3页Geriatrics & Health Care

摘　　要：对265例60～94岁的冠心病人,观察其血清总胆固醇(TC)和高密度脂蛋白胆固醇(HDL-C)以及TC:HDL-C比值受性别、高血压、糖尿病和吸烟等因素影响的情况。随访病人平均4.4年,了解急性心肌梗塞(AMI)和心原性猝死(SCD)的发生情况。结果表明,女性和不吸烟者的TC和HDL-C水平较高;发生AMI和SCD者的HDL-C降低、TC:HDL-C比值升高。Kaplan-Meier分析,HDL-C<0.9mmol/L和TC:HDL-C>4.5的病人的AMI和SCD发生率显著增高。结果提示,低HDL-C水平和高TC:HDL-C比值是老年冠心病人再发心脏事件的重要危险因素。临床应重视低HDL-C的治疗。Two hundred and sixty five patients with coronary artery disease (CAD) aged 60- 94 years old were examined about the association of the factors of sex, systemic hypertension, diabetes mellitus and smoking with total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and the ratio of TC to HDL-C. All the patients were follow-up for an average of 4.4 years and were observed for the occurrence of acute myocardial infarction (AMI) and sudden cardiac death (SCD). In t test analysis, the levels of TC and HDL-C of females and non-smokers were comparatively high, the level of HDL-C dropped and the ratio of TC to HDL-C raised in the patients with AMI and SCD. When the patients' level of HDL-C < 0.9 mmol / L or the ratio of TC to HDL-C >4.5, the rates of occurrence of AMI and SCD were significantly increased computed from Kaplan-Meier survival curves. The results of the study indicated that low level HDL-C and high ratio of TC to HDL-C are important risk factors of recurrent heart event in elderly patients with CAD. Attention should be payed to the treatment of low level HDL-C.

关 键 词：HDL-C 病人 再发心脏事件 TC AMI 老年冠心病 SCD 水平 情况 比值 

分 类 号：R541.4[医药卫生—心血管疾病] R542.22[医药卫生—内科学]