依普拉封对摘除卵巢所致大鼠骨质疏松的作用  

Effect of Ipriflavone on Ovariectomy-Induced Osteoporosis in Rats

作　　者：石明健[1] 刘惟莞[1] 李宗桃[1] 王红英[1] 邓思清[1] 田秋霖[1] 

机构地区：[1]湖北医科大学药理学教研室,武汉滨湖制药厂药物研究室,湖北医科大学化学教研室

出　　处：《中国骨质疏松杂志》1996年第1期70-72,66,共4页Chinese Journal of Osteoporosis

摘　　要：本文研究了依普拉封对摘除卵巢所致雌性大鼠骨质疏松的治疗作用。摘除１２个月龄雌性大鼠双侧卵巢，由于雌激素不足，造成骨质疏松。使用依普拉封尿钙排出降低、血清碱性磷酸酶活性升高、血清骨钙素含量增加。股骨Ｘ光片图像分析结果表明：依普拉封提高股骨远端骨骺端骨密度、骨干皮质厚度、皮质密度、骨干髓质密度及骨密度。同时，依普拉封可增加骨干重、灰重和骨钙含量。提示依普拉封可改善摘除卵巢大鼠所致的骨质疏松。The effect of Ipriflavone on osteoporosis after ovaryexcision is discussed.Experiments have shown that Ipriflavone decreased urine calcium and increased serum alkaline phosphatase activity and level of osteocalcin. Microdensitometrical analysis of the roentgenograph of the femurs confirmed that Ipriflavone increased the density of both the distal metaphysis and the marrow region of the diaphysis as well as the cortical thickness index. Furthermore,Ipriflavone could lead to obvious increase in dry weight,ash weight and mineral content of femurs. It is indicated that Ipriflavone is effective in preventing and treating osteoporosis induced by ovaryexcision.

关 键 词：依普拉封 骨质疏松 摘除 卵巢 雌性大鼠 骨密度 骨干 成骨 股骨远端 皮质厚度 

分 类 号：R681[医药卫生—骨科学] R285.5[医药卫生—外科学]