肾性骨病的矿物代谢与调节激素关系  

Relationship between mineral metabolism and regulating hormones in renal osteodystrophy

作　　者：王维力[1] 朱淑兰[1] 赵立全[1] 尹维[1] 翟德佩[1] 

机构地区：[1]天津医科大学总医院内分泌科

出　　处：《中国骨质疏松杂志》1996年第2期45-47,49,共4页Chinese Journal of Osteoporosis

摘　　要：本文报道肾性骨营养不良和钙、磷与调节激素变化的关系．８２例中男性４３例，女性３９例。发病年龄８～７１岁，平均４４岁。病程１～１０年，平均３．２±１．４年。骨质变化以骨质疏松３９例占多数，其次为骨软化和／或佝偻病２３例，其它有纤维囊性骨炎１０例，骨硬化１０例。其中１８例骨畸形和１５例骨折。血钙平均值低于正常（１．５４±０．４１ｍｍｏ１／Ｌ），血磷升高（１．７９±０．７６ｍｍｏ１／Ｌ），２４小时尿钙与尿磷减少。血清甲状旁腺激素（ＰＴＨ）、降钙素（ＣＴ）、骨钙素（ＢＧＰ）、酸性磷酸酶（ＡＣＰ）、抗酒石酸酸性磷酸酶（ＴｒＡＣＰ）、碱性磷酸酶（ＡＫＰ）、血清尿素氮（ＢＵＮ）与血清肌酐（Ｃｒ）均升高，且差异具有显著性（Ｐ＜０．０５～０．０１）。In order to study the relationship between mineral metabolism and regulating hormones in chronic renal osteodystrophy, eighty-two cases of chronic renal osteodystrophy (43 men and 39 women)were observed for metabolic change in Ca, P, BUN, PTH, CT, BGP, ACP, TRACP, urine Ca, P, and Hyp. Their mean age was 44 years (8-71). The average course was 3.2 years (1-10). Roentgenologically confirmed 39 cases of osteoporosis, 23 of osteomalacia or rickets. 10 of osteitis fibrosa and 10 of osteosclerosis 15 patients with fractures, and 18 with deformity. The mean values of serum Ca were decreased,and serum P increased in 82 patients(p<0.01). 24 hour urine Ca, P concentrations decreased and Hyp concentrations increased. The mean values of serum PTH, CT, BGP, BUN, Cr, AKP, ACP, and TRACP significantly increased (P<0.05-0.01).

关 键 词：肾性骨病 甲状旁腺激素 升高 调节 囊性 抗酒石酸酸性磷酸酶 PTH ACP 骨硬化 尿钙 

分 类 号：R692[医药卫生—泌尿科学] R681[医药卫生—外科学]