患儿接受强的松治疗前后骨代谢指标的改变  

Changes of bone metabolic markers in children treated with prednisone

作　　者：赵丹慧[1] 薛延[1] 贾维维[1] 张海文[1] 陈文利[1] 金玉[1] 

机构地区：[1]北京积水潭医院创伤骨科研究所生化研究室,北京医科大学附属第一医院儿科

出　　处：《中国骨质疏松杂志》1996年第2期59-61,共3页Chinese Journal of Osteoporosis

摘　　要：本研究对３０名使用强的松治疗的患儿治疗前及治疗６个月时的骨代谢指标尿Ｃｒｏｓｓｌａｐｓ／Ｃｒ、ＮＴＸ／Ｃｒ、Ｈｏｐ－Ｃｒ及血清２５－ＯＨＤ进行了比较。同时测定了１３名患儿治疗前后的骨密度，并将４种治疗指标与正常儿童进行了比较。结果表明：（１）尿Ｃｒｏｓｓｌａｐｓ／Ｃｒ、ＮＴＸ／Ｃｒ、是继发性骨量丢失的敏感指标；（２）强的松有促进骨吸收的作用；（３）骨吸收生化指标的改变先于骨密度的改变。Four bone biochemical markers in urine and blood were studied in 30 children with nephrotic syndrome and other immune diseases. Urine Crosslaps/Cr, NTX/Cr, Hop/Cr ratios and serum levels of 25-OHD were measured before and after treatment with prednisone. BMD were measured in thirteen of them. The results indicate that the ratios of Crosslaps/Cr and NTX/Cr are sensitive markers of bone resorption for monitoring secondary bone loss; prednisone can promote bone resorption; the changes in markers of bone resorption are earlier than that in BMD.

关 键 词：强的松 骨代谢指标 治疗前后 改变 患儿 骨吸收 骨密度 骨量丢失 治疗指标 继发性 

分 类 号：R681[医药卫生—骨科学] R692[医药卫生—外科学]