大鼠模型骨矿密度测量的新方法  

A new method for measuring bone mineral density of rat models

作　　者：鄢中付[1] 钟鸣[1] 祝光荣[1] 姜俊德[1] 鄢铃[1] 宿红[1] 

机构地区：[1]成都中国测试技术研究院

出　　处：《中国骨质疏松杂志》1996年第3期4-6,共3页Chinese Journal of Osteoporosis

摘　　要：本文介绍使用活性极弱的１２５Ｉ液体源测量大鼠模型骨矿密度的新方法。利用目前国内使用较多的ＳＰＡ─４型骨矿分析仪［１］，在其扫描臂上部的下端再加装一个有Φ２．５×６的出射孔的铅室，铅室内部尺寸可以安装１２５Ｉ液体源标准安瓿瓶，瓶内有０．１～０．２ｍｌ液体，其１２５Ｉ活性为１×Ｉ０９Ｂｑ（２７ｍＣｉ），１２５Ｉ的２７．５ｋｅＶ低能γ射线由铅室的出射孔向下发出。改进后即把检测人的２４ｌＡｍ单光子骨矿密度仪变成大鼠模型的１２５Ｉ单光子骨矿密度仪。检测精度为±１．７％，不确定度为（３～５）％。This paper describes a method using a liquid radioactive source (125)I with very weak activity to measure the bone mineral density of rat models. A lead chamber with ф2. 5×6 outgoing hole is mounted on the upper end of scanner arm of a SPA-4 type bone mineral analyzer[1]. The inner space of lead chamber may contain a standard ampere-bottle with (125)I liquid source of 0. l￣0. 2 ml and the (125)I activity emits low energy γ-rays of 1×109Bq (27mCi) with main energy of 27. 5 keV. The γ-rays are emitted from the outgoing hole to form a beam and pass through the specimen of low bone mineral density. By such improvement an (241)Am single photon bone mineral analyser for humans can be changed into an (125)I single photon bone mineral analyser for rat models. The measurement precision is±1. 7% and the uncertainty is 3% ￣5%.

关 键 词：^125I 大鼠模型 骨矿密度 单光子 活性 新方法 安瓿瓶 液体 分析仪 国内 

分 类 号：R681[医药卫生—骨科学] R735.9[医药卫生—外科学]