糖尿病患者血清BGP与骨密度变化的研究  

Study on changes of Serum bone Gla-protein and bon mineral density in diabetics

作　　者：潘时中[1] 严孙杰[1] 张松菁[1] 汤冰[1] 王敏[1] 

机构地区：[1]福建医学院附属第一医院内分泌科

出　　处：《中国骨质疏松杂志》1996年第3期46-47,85,共3页Chinese Journal of Osteoporosis

摘　　要：本文应用放射免疫分析方法对６０例正常人及７４例糖尿病患者的血清ＢＧＰ进行了测定，并就其与ＢＭＤ、血Ｃａ、Ｐ及ＡＫＰ等进行比较分析。结果表明：糖尿病患者血清ＢＧＰ明显降低，而血Ｃａ、Ｐ及ＡＫＰ仍在正常范围，血清ＢＧＰ与ＢＭＤ呈负相关。说明血清ＢＧＰ测定与ＢＭＤ一样可以作为骨质疏松、糖尿病等代谢性骨病诊断与研究的一种敏感指标。A determination was made of serum BGP in 60 normal subjects and 75 cases of diabetes with radioimmunoassay, and a comparative analysis was made of BMD, serum Ca, P, AKP. The results showed that serum BGP in diabetics dropped significantly (0. 0l<P<0.05), but serum Ca, P, AKP remained normal. Serum BGP and BMD showed negative correlation (r=-0.326, P<0.05). This indicates that determination of serum BGP, like BMD, can be used as a sensitive index for the diagnosis and study of such metabolic bone diseases as osteoporosis and diabetes.

关 键 词：血清 糖尿病患者 BMD BGP 骨密度 诊断 正常范围 代谢性骨病 AKP 放射免疫分析方法 

分 类 号：R681[医药卫生—骨科学] R587.1[医药卫生—外科学]