美托洛尔对人体心脏变时性反应及肝药酶的影响  

THE INFLUENCE OF METOPROLOL ON CARDIAC CHRONOTROPIC RESPONSE AND LIVER DRUG MICROSOME ENZYME IN MAN

作　　者：吴士尧[1] 徐济民[1] 

机构地区：[1]上海第二医科大学附属第九人民医院心血管病研究室

出　　处：《中国临床药理学杂志》1993年第1期13-17,共5页The Chinese Journal of Clinical Pharmacology

摘　　要：10例健康受试者口服美托洛尔25mg,每日二次,连续七天后,异丙基肾上腺素的心脏变时性剂量(chronotropic dose_(25),CD_(25))从1.2±0.5μg增加到3.5±0.9μg(p<0.01),立、卧位择时心率平均减慢10.7%和14.6%(p<0.01);安替比林Cl降低(从0.02023±0.00526 l/h降至0.01823±0.00434 1/h,p<0.05),T1/2和Vd无明显改变。说明短期使用美托洛尔能够产生β—受体阻滞作用和肝药酶的抑制。After taking metoprolol 25mg twice daily for 7 days in 10 volunteers, chronotropic dose_(25) (CD_(25)) was increased to 3. 5±0. 9μg from 1. 2±0. 5μg; the mean β-receptor block index was 4. 4, the chrono-heart rate in supine (14. 6%) and standing (10. 7%) positions decreased respectively and the clearance rate of antipyrine decreased to 0. 01823±0. 00434 L/h from a pre-drug level of 0. 02023±0. 00526 L/h(p<0. 05). No change was found in the half-life and distribution volume of antipyrine. The results indicated that the metoprolol used in short-term and small dose could produce the β-receptor blocking effect and the inhibition of liver drug microsome enzyme.

关 键 词：美托洛尔 肾上腺素 安替比林 

分 类 号：R972[医药卫生—药品]