四环类抗抑郁药—麦普替林及其代谢产物的药代动力学研究  

PHARMACOKINETIC STUDIES OF A TETRACYCLIC ANTIDEPRESSANT-MAPROTILINE

作　　者：张岱[1] 刘家良[1] 常明[2] 舒良[1] 沈渔村[1] 刘平[1] 

机构地区：[1]北京医科大学精神卫生研究所,北京100083 [2]北京医科大学药理教研室,北京100083

出　　处：《中国临床药理学杂志》1993年第3期157-160,150,共5页The Chinese Journal of Clinical Pharmacology

摘　　要：本文报道了8例青年健康志愿者口服50mg麦普替林的药代动力学参数。麦普替林的药时曲线符合一室线性动力学模型,T_(peak)=12.03±8.41h;t_(1/2ke)=57.7±37.4h;CL=49.47±47.02 l/h;Vd=2754±1230 l。麦普替林的主要代谢产物去甲麦普替林的药时曲线亦符合一室线性动力学,其T_(peak)=9.55±7.54h;t_(1/2ke)=138.5±107.5h;CL=247.5±151.2 l/h;Vd=6577±3511 l。本文还对药代动力学参数的意义进行了讨论。Eight healthy young adult volunteers received single 50 mg oral doses of maprotilinehydrochloride tablet. The concentration-time curve of maprotiline fitted in with one compartment kinetic model. The parameters of maprotiline were as follows: Tpeak=12.03±8.41 h; t1/2ke=57.7±37.4h; CL=49.47±47.02 l/h; Vd=2754±1230 l. The concentration time curve of its metabolite,desmethyl maprotiline, fitted in with one compartment kinetic model. Tpeak=9.55±7.54 h; t1/2 ke=138.5±107.5 h; CL=247.5±151.2 l/h; Vd=6577±3511 l. The clinical significance of the pharmacoki-netic parameters was discussed.

关 键 词：麦普替林 药代动力学 抗抑郁药 

分 类 号：R969.1[医药卫生—药理学]