骨代谢生化指标随年龄的变化及其临床意义  

Age related changes in biochemical markers of hone metabolism and their clinical significances

作　　者：薛延[1,2,3] 贾维维[1,2,3] 张海文[1,2,3] 陈文利[1,2,3] 赵丹慧[1,2,3] 褚为靖[1,2,3] 何玉香[1,2,3] 

机构地区：[1]北京积水潭医院创伤骨科研究所生化研究室 [2]北京积水潭医院创伤骨科研究所骨库 [3]北京积水潭医院创伤骨科研究所放免研究室

出　　处：《中国骨质疏松杂志》1995年第2期87-91,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金;北京市科委基金

摘　　要：本文收集了北京地区１９２８名不同年龄（０～８７岁）健康人及５３４５例２０余种疾病患者空腹尿及血，并对其骨代谢生化指标进行测定。结果表明：血清２５羟基维生素Ｄ（２５ＯＨＤ），碱性磷酸酶（ＡＬＰ），骨钙素（ＢＧＰ），甲状旁腺激素（ＰＴＨ），尿Ⅰ型胶原交联Ｎ末端肽与肌酐比值（ＮＴＸ／Ｃｒ）及羟脯氨酸与肌酐比值（ＨＯＰ／Ｃｒ）与年龄显著相关。血清２５ＯＨＤ，ＢＧＰ，尿ＮＴＸ／Ｃｒ及ＨＯＰ／Ｃｒ可用于预测骨量。１，２５（ＯＮ）２Ｄ３，２５ＯＨＤ，ＮＴＸ／Ｃｒ和ＮＯＰ／Ｃｒ可用于区分绝经前与绝经后骨质疏松妇女。与年龄有关的骨丢失可能与１，２５（ＯＨ）２Ｄ３的降低、ＰＴＨ的升高及肾功能减退有关；绝经后骨丢失与雌激素缺乏有关。Fasting urine and blood samples were collected from 1928 healthy subjects aged 0～87 years and 5345 patients in Beijing and the biochemical markers were measured. The results indicated that serum 25 hydroxy vitamin D(25OHD), alkaline phosphatase(ALP), osteocalcin(BGP), parathyroid hormone(PTH) urine type I collegen crosslinked N-telopeptides creatinine ratio(NTX/Cr) and hydroxyproline creatinine ratio (HOP/Cr) were significant correlates with age. Serum 25OHD, BGP,urine NTX/Cr and HOP/Cr could be used to predict bone mass. 1, 25 ((OH)2D3, 25OHD,NTX/Cr, HOP/Cr are able to discriminate between premenopansal and late osteoprotic patients. Agerelated bone loss may be due to a fall in 1,25(OH)2D3 and a rise in PTH and renal dysfunction. Postmenopausal bone loss could be due to estrogen deficiency.

关 键 词：骨代谢生化指标 不同年龄 PTH 骨丢失 绝经后 临床意义 血清 肌酐比值 甲状旁腺激素 疾病患者 

分 类 号：R681[医药卫生—骨科学] R971.2[医药卫生—外科学]