麻风病人体内超氧化物歧化酶与脂质过氧化物含量的变化  

Contents of Superoxide Dismutase and Lipid-Peroxide in the Blood of Leprosy Patients

作　　者：张志渊[1] 黄林邦 

机构地区：[1]赣南医学院 [2]病理生理教研室

出　　处：《中国麻风杂志》1993年第2期78-80,共3页

基　　金：国家自然科学基金会资助项目(39060033)

摘　　要：摘要超氧阴离子(·o2)是吞噬细胞杀菌的重要物质。超氧化物歧化酶(SOD)直接影响着体内·o2的浓度。作者分析麻风病人体内SOD和脂质过氧化物(LPO)的变化,以探讨自由基代谢紊乱与麻风发病的关系。结果显示LL、BL现症病人SOD含量显著高于现症TT和BT病人、麻风治愈者、非麻风皮肤病人及正常对照组(P<O.05),而其LPO则明显低于非麻风皮肤病人组(P<O.01)。说明麻风病人体内SOD含量增高,与麻风发病有关。ABSTRACT The superoxide anion (. O2 ) is an important bactericide of phagocytes. The concen-tration of . Of in the body is directly affected by superoxide dismutase (SOD). To clarify the re-lationship between the metabolic disorder of free radical in leprosy patients and the pathogenesis of leprosy, the content changes of SOD and lipidperoxide (LPO) in the body of persons with leprosy (LL,BL,TT and BT)and common dermatoses and healthy controls were measured. The results showed that in active MB leprosy patients the content of SOD is higher than that in the MB cures ,PB leprosy patients,persons with dermatoses and controls (P<0. 05) ,but the content of LPO is lower than that in the persons with dermatoses and controls (P<0. 01). It is suggested that the increased concentration of SOD in the blood of MB leprosy patients might be related to pathogene-sis of leprosy.

关 键 词：麻风 自由基 SOD 过氧化脂质 

分 类 号：R755.03[医药卫生—皮肤病学与性病学]