人胆囊组织内巨噬细胞、肿瘤坏死因子、IL-1的含量变化与胆结石的关系  

THE RELATIONSHIP OF MACROPHAGES, TUMOR NECROSIS FACTOR AND INTERLEUKIN 1 WITH THE FORMATION OF HUMAN CHOLESTEROL GALLSTONES

作　　者：别平[1] 黄志强[1] 韩本立[1] 王敖川[1] 杨可桢[1] 彭志明[1] 段恒春[1] 李昆[1] 

机构地区：[1]第三军医大学西南医院肝胆外科,解放军总医院肝胆外科

出　　处：《普外基础与临床杂志》1995年第3期140-142,共3页

摘　　要：收集人体胆囊６３份，其中１６份无结石为非结石组，４７份为有胆固醇结石之胆囊为结石组。测定胆囊组织巨噬细胞（Ｍ）数量、胆囊粘膜肿瘤坏死因子（ＴＮＦ）、白细胞介素－１（ＩＬ－１）的含量。结果：结石组胆囊组织内Ｍ数量明显高于非结石组（分别为４１０１．９０±２９５．７２、５７２．１３±３０．０７ＡＵ，Ｐ＜０．０１）；结石组胆囊粘膜ＴＮＦ、ＩＬ－１的含量亦显著高于非结石组（ＴＮＦ分别为１８．１２±２．０３、４．４５±０．３９ｎｇ／ｍｇ，Ｐ＜０．００１。ＩＬ－１分别为１０２．４２±７．８４、６６．７５±９．５０ｕ／ｍｇ蛋白，Ｐ＜０．０５）。结果提示：胆囊组织Ｍ中的活化及其释放的ＴＮＦ、ＩＬ－１与胆囊组织炎症反应和胆囊结石的形成有内在联系。63 normal human gallbladders (non-stone group) and 47 inflammed cholesterol stone gallbladders (stone group) were assayed for the amount of macrophages (M), the levels of tumor necrosis factor (TNF)and interleukin 1 (IL-1). It was found that in stone group, the amount of M was significantly higher than in non-stone group (M 4101.90±295.72 vs 572.13±30.07 AU, P<0.01). The levels of TNF and IL-1 released mainly from the M in stone group were also significantly increased in comparison with those in non-stone group (TNF 18.12±2.03 vs 4.45±0.39 ng/mg, P<0.001; IL-1102.42±7.84 vs 66.7±9.50u/mg protein, P<0.05). These results suggest that the activited M andincreases of TNF, IL-1 may be closely related to the inflammatory reaction in gallbladders and the formation of cholesterol gallstones.

关 键 词：胆囊粘膜 IL-1 TNF 组织内 非结石 肿瘤坏死因子 巨噬细胞 胆结石 含量 胆固醇结石 

分 类 号：R657[医药卫生—外科学] R575[医药卫生—临床医学]