沙棘蜂王浆口服液抗辐射损伤作用的研究  

EXPERIMENTAL STUDY ON THE ANTI-EFFECTS OF ORAL-INTAKE LIQUID OF FRUCTUS HIPPOPHAE ROYAL JELLY (OLFHRJ)TO RADIATION DAMAGE

作　　者：曹军[1] 孙晓杰[1] 王滨[2] 李希哲 王润华 马凤勤 王晓杰 

机构地区：[1]齐齐哈尔医学院生物化学教研室 [2]齐齐哈尔医学院生理学教研室 [3]讷河市卫生防疫站 [4]依安县卫生防疫站

出　　处：《齐齐哈尔医学院学报》1995年第4期244-246,共3页Journal of Qiqihar Medical University

摘　　要：从亚细胞水平探讨了沙棘蜂王浆口服液抗辐射损伤的作用,从抗自由基损伤角度阐述了其作用机制,并与维生素E抗辐射作用进行了对比性研究.结果显示小鼠经8.5Gyγ射线一次性全身照射后,本口服液小组鼠肝线粒体脂质过氧化物含量明显低于辐射损伤组(P<0.01)和维生素E对照组(P<0.01)F Mn-SOD和CuZn-SOD活力均明显高于辐射损伤组(P<0.01),而与维生素E组无显著差别(P<0.05);GSH-P_x活力明高显于辐射损伤组和维生素E组(P<0.01).We studied the anti-effects of the OLFHRJ to the radiation damage in the subcellular degree and compared the anti-effects of the OLFHRJ to the radiation damage with the vitamine E. The results showed that the level of the liquid peroxide in the hepetic mitochondria in the OLFHRJ group mice were significantly lower than the vitamine E group mice on the third day after the whole body exposure with 8.5 Gy of 60Co r-ray (P<0.01) . The activities of Mn-SOD and Cu Zn-SOD in the OLFHRJ group mice both were significantly higher than the radiation damage group mice (P<0.01). But their activities weren't different from the vitamine E group mice (P>0.05).The activity of GSH-Px in the OLFHRJ group mice were significantly higher than the radiation damage group mice and the vitamine E group mice ( P<0.01).

关 键 词：抗辐射损伤 口服液 维生素E 对比性研究 对照组 鼠肝 脂质过氧化物 小组 射线 抗自由基损伤 

分 类 号：R285.5[医药卫生—中药学] R282.74[医药卫生—中医学]