中国广东地区汉族人MHC补体单倍型的分析  

Analysis of MHC complotype of han nationality chinese in guangdong area

作　　者：陈仁馨[1] 黄为民[2] 聂晓波[1] 刘新[1] 

机构地区：[1]第一军医大学免疫学教研室,广州510515 [2]第一军医大学附属珠江医院

出　　处：《中国免疫学杂志》1993年第4期205-207,共3页Chinese Journal of Immunology

基　　金：广东省科学技术委员会科学基金资助课题(89226)

摘　　要：用国际补体参考实验室方法。首次对广东地区正常汉族家系126条染色体作了补体单倍型检测与分析。共发现18个补体单倍型,居前四位者为SC31、SC42、SC32、和SC41。其中有7个型呈连锁不平衡。4个位点等位基因分别是BF、C2、C4A、C4B。BF 以BFS;C2以C2C;C4A以C4A3和C4A4;C4B 以C482和C481频率居高。C4AQO 占4.8%,C4BQO 占1.2%,本文主要补体单倍型频率和黄、白人种接近。和日本人及东南亚地区民族接近。但和黑种人差异较大。并对地区间频率差异意义做了讨论。It was the first time that the complotypes of 84 chromosomes from Han nationality healthy Chinese families investigated and analyzed in Guangdong are a with the methods adopted from the international complement reference laboratory.The results showed 18 various complolypes were identified.The precedent complotypes are SC31,SC42,SC32 and SC41.There were 7 com- potypes of them existing the linkage disequilibria.The highest allotypes gene frequencies of the four loci of complotypes were respectively as follows,BF S for BF alleles,C2C for C2 alleles, C4A3 and C4A4 for C4A alleles,C4B2 and C4B1 for C4B alleles.The C4AQO allele for C4A lo- cus was 4.8% and 1.2%C4BQO alleles for C4B locus.The frequencies of major complolypes from the data showed the similarities among Mongolian,Caucasian,Japanese and south eastern Asia populations.The significance of the different frepuencies between the complotypes has been discussed.

关 键 词：补体 单倍型 MHC 广东地区 汉族 

分 类 号：R392.2[医药卫生—免疫学]