群体反应性抗体(PRA)检测——附180例报告  

De Tec tion of panel Reqcttive Antibody—180 cases.

作　　者：肖露露[1] 肖巧珍[1] 张仕光[2] 吴培根[2] 纪玉莲[2] 

机构地区：[1]广州血液中心器官移植配型实验室,广州510060 [2]中山医科大学附属临床医学院肾内科

出　　处：《中国免疫学杂志》1993年第4期249-250,共2页Chinese Journal of Immunology

摘　　要：本文研究了群体反应性抗体(PRA)对肾移植的影响,发现PRA 是免疫应答抗体,高PRA 与严重排斥反应强关联,亦是丧失移植肾的重要指征,并讨论了PRA 和CDC 作为HLA 组织配型对肾移植中提高人/肾双存活率的应用意义,证实PRA 比CDC 敏感性高。Observations on the effects of panel reactive antibody on renal transplantion-with 180 cases reports.This paper deals with the observations on the effects of panel reactive antibody (PRA) on renal transplantation.The rdsults showed that PRA is an immune response antibody.High PRA correlated with increased severity of rejection and was one of the high-risk factors in renal transplantation.PRA was a more susceptible method than complentment dependent cytotoxity (CDC)using in HLA tissue matching for increasing the survival rates of recipient/kidney in re- nal transplantation.The application of PRA and CDC in renal transplantation was discussed.

关 键 词：组织相容性 抗体 肾移植 排斥反应 

分 类 号：R699.203[医药卫生—泌尿科学]