维生素C对再灌注心肌损伤的保护作用  

PROTECTIVE EFFECT OF VITAMIN C ON MYOCARDIAL INJURY DUE TO REPERFUSION

作　　者：刘岐山[1] 叶铭[1] 张运生[1] 吴再彬[1] 宋继志[2] 洪大蓉[2] 祝纪山[2] 

机构地区：[1]南京铁道医学院医学科学研究所 [2]南京铁道医学院电子显微镜室

出　　处：《南京铁道医学院学报》1991年第4期203-206,共4页Journal of Nanjing Railway Medical College

基　　金：江苏省科委资助课题

摘　　要：用健康 SD 大鼠复制心肌再灌注模型,动态监测维生素 C 治疗组与盐水对照组的血流动力学与心电图,并采用心肌电镜形态计量。实验结果表明,Vitc 能显著除低再灌注心律失常发生率与室颤死亡率;并能明显减轻心肌结构损害和功能异常,本实验结果支持自由基在心肌再灌注损伤发病机制中起重要作用的假说。Myocardial reperfusion model was established on 40 healthy Sprague-Dawley rats. The experimental animals were divided into saline control and vitamin-C-treated groups The parameters of hemodynamics were measured witha RM-6000 polygraph and the electron microscopic cell morphometry for myocardium was used.the results indicated that vitamin C remarkebly induced the incidence of arrhythmias after myocardial repe- rfusion and the mortality from ventricular fibrillation.In addition,vitamin C has protective effects on struture damage and depressed contractile function of myocardium caused dy ischemic reperfusion.Our results support the hypothesis that oxygen-free redical plays an important role in the pathogenesis of damage caused by reperfusion.

关 键 词：维生素C 再灌注心律失常 心电图 保护作用 心肌损伤 心肌结构 对照组 起重 复耕 动态监测 

分 类 号：R542[医药卫生—心血管疾病] R541[医药卫生—内科学]