铅毒性效应的性别差异  

Differences of Toxic Effects of Lead Between Sexs

作　　者：陈自强[1] 于继慧[1] 张瑞稳[1] 潘志挚[2] 屈家瑛[1] 

机构地区：[1]上海医科大学劳动卫生学教研室 [2]上海医科大学预防医学研究所

出　　处：《中国工业医学杂志》1989年第3期11-13,35,共4页Chinese Journal of Industrial Medicine

摘　　要：本文研究了铅毒性效应的性别差异。选择98名铅作业工人为接触组,另以39名无毒物接触史的健康者为对照组。研究表明:1.与对照组比,症状得分、卟啉代谢物明显升高时的血铅水平,女性低于男性。2.在相同血铅水平下,女性症状得分、卟啉代谢物明显高于男性;神经传导速度则显著低于男性。 以上结果提示,女性对铅毒性较男性敏感。The differences of the toxic effects of leadbetween sexs were studied. Ninety eightworkers occupationally exposed to lead werechosen as an exposure group and 39 healthysubjecis not exposed to any harmful factorswere used as a control group. The results revealed: 1. The level of Pb-Bin female was lower than that in male whenthe scores of the symptoms, the levels of themetabolites of porphyrin were significantlyincreased,as compared with the control group,2. Under the condition at the same levels ofPb-B in female and male, the scores of the symptoms, the levels of the metabolites ofporphyrin were significantly higher in femalethan in male and the nerve conduction velo-cities were significartily lower in female thanin male. The results mentioned above indicated thatthe toxic effects of lead on female were moresusceptible than those on male.

关 键 词：铅毒性 男性 对照组 血铅水平 女性 接触史 卟啉代谢 无毒 研究 敏感 

分 类 号：R135[医药卫生—劳动卫生] R725.952[医药卫生—公共卫生与预防医学]