六种化学治疗药物的组织动力学研究  

STUDIES ON TISSUE PHARMACKINETICS AND RESIDUES OF SIX CHEMOTHERAPEUTANTS

作　　者：李涛[1] 乔桂林[1] 胡功政 邱银生 张秀英[1] 孟凡东 郭文欣 叶红丽 

机构地区：[1]东北农业大学,哈尔滨150030

出　　处：《中国农业科学》1993年第4期79-85,共7页Scientia Agricultura Sinica

摘　　要：本文采用高效液相色谱(HPLC)法研究了青霉素G、磺胺-6-甲氧嘧啶(SMM)、磺胺喹噁啉(SO)、丙硫苯咪唑及其代谢物亚砜和砜、喹乙醇与头孢三嗪在鸡、兔体内的血药动力学与组织药物动力学特征。运用回归分析的方法研究了血浆与多种组织之间药物浓度的动态变化规律,并根据血桨及多种组织中的药物消除规律推算出达到一定残留水平所需时间。Pharmacokinetic processes of penicillin , sulfamonomethoxine, snifaquinoxaline , albendazole and its metabolites . olaqnindox cetriaxone in plasma and tissues of broilers and rabbits were studied with HPLC procedure. Regression analysis methods were used for studying the dynamic relationship of drug concentrations between plasma and various tissues ; the time when drug residues reduced to given level were predicated according to the elimination regularity of plasma and these tissues

关 键 词：化疗药物 组织药动学 残留量 鸡 

分 类 号：S831.1[农业科学—畜牧学]