不稳定心绞痛与血小板CD63、CD62P及血浆PAI-1、C-RP的关系  

Changes of platelet CD63,CD62P,plasminogen activator inhibitor-1 and C-reactive protein in patients with unstable angina

作　　者：罗助荣[1] 郑冰[2] 

机构地区：[1]解放军福州总医院心内科,福州350025 [2]福建省第二人民医院检验科

出　　处：《中国急救医学》2001年第2期76-78,共3页Chinese Journal of Critical Care Medicine

摘　　要：目的　探讨不稳定心绞痛 (UAP)血小板胞浆内α -颗粒上的膜糖蛋白 (CD6 2P)及溶酶体膜糖蛋白 (CD6 3)与血浆纤溶酶原活物 - 1(PAI- 1)、C -反应蛋白 (C -RP)的关系 ,并揭示其在UAP发生及发展中的意义。方法　应用流式细胞术检测 5 9例UAP患者血小板表面活性标志蛋白CD6 3、CD6 2P ,同时检测血浆PAI - 1及C -RP水平。结果　①与对照组比较 ,UAP患者CD6 3、CD6 2P、PAI- 1及C -RP水平明显增高 (P <0 0 5或P <0 0 1) ;②CD6 3、CD6 2P与PAI- 1及C -RP呈正相关 ;③CD6 3、CD6 2P及PAI- 1、C -RP水平在心绞痛发作状态比发作前及发作后状态明显增高 (P <0 0 5或P <0 0 1) ;④随着UAP患者Braunwald分级及冠状动脉病变支数的增加 ,CD6 3、CD6 2P及PAI- 1、C -RP水平均有增加趋势。结论　血小板活化、纤溶机制及炎症反应在UAP的发生及发展中共同作用 ;Objective To explore the correlation between platelet activation factor CD63、CD62P and plasma plasminogen activator inhibitor-1(PAI-1), C-reactive protein(C-RP)in patients with unstable angina(UAP).Methods Platelet activation factor CD63, CD62P were detected by flow cytometry,and plasma PAI-1, C-RP were measured by enzyme-immeoassay in UAP.Results ①Platelet activation factor CD63、CD62P and plasma PAI-1 activity, serum C-RP concentration were significantly higher than those of the normal subjects and the stable angina(SAP)subjects( P< 0.05 or P< 0.01);②There were correlation between platelet CD63、CD62P and plasma PAI-1, C-RP;③The increase of all indicators were much obvious higher in angina attack than before angina attack and in relief( P< 0.05 or P< 0.01);④There were positive correlation between all indicators and the degree of angina and coronary stenosis.Conclusions Platelet activation,PAI-1 activity, C-RP involved in the development of UAP,and predicted the prongnosis of UAP. [

关 键 词：不稳定心绞痛 血小板CD63 CD62P 血浆PAI-1 C-RP UAP 

分 类 号：R541.4[医药卫生—心血管疾病] R446.11[医药卫生—内科学]