水合肼还原芳硝基物的研究  

Reduction of Aromatic Nitro Compounds with Hydrazine Hydrate

作　　者：张竹霞[1] 吕荣文[1] 张珂珂[1] 高昆玉[1] 

机构地区：[1]大连理工大学精细化工国家重点实验室,辽宁大连116012

出　　处：《精细化工》2001年第4期239-242,共4页Fine Chemicals

摘　　要：以Pd C为催化剂 ,水合肼为还原剂研究了p 硝基乙酰苯胺、p 硝基氯苯以及 3 硝基 4 甲氧基乙酰苯胺的还原反应 ,反应在液相色谱跟踪下进行。80℃下p 硝基乙酰苯胺及p 硝基氯苯还原转化率达 10 0 %所需的条件分别为 :n(p NO2 C6 H4NHCOCH3)∶n(N2 H4H2 O) =1 0∶1 6、催化剂用量 11 33g (molp 硝基乙酰苯胺 )、反应时间 3h ;n(p NO2 C6 H4Cl)∶n(N2 H4H2 O) =1 0∶1 8、催化剂用量 10g (molp 硝基氯苯 )、反应时间 2 0min ;还原最终产物组成单一 。p Nitroacetanilide, p nitrochlorobenzene and 3 nitro 4 methoxyacetanilide were reduced by hydrazine hydrate in the presence of Pd/C catalyst.The reduction of three aromatic nitro compounds was tracked by monitoring with HPLC.The conversion of p nitroacetanilide and p nitrochlorobenzene was 100% when n(p NO 2C 6H 4NHCOCH 3)∶ n (N 2H 4H 2O)=1 0∶1 6,Pt/C=11 33 g/mol p nitroacetanilide,reaction time=3 h and reaction temperature=80 ℃, and n(p NO 2C 6H 4Cl)∶ n (N 2H 4H 2O)=1 0∶1 8,Pt/C=10 g/mol p nitrochlorobenzene,reaction time=20 min and reaction temperature=80 ℃.The final products were the corresponding amino compounds.

关 键 词：p-硝基乙酰苯胺 p-硝基氯苯 3-硝基-4-甲氧基乙酰苯胺 水合肼 

分 类 号：TQ246.1[化学工程—有机化工]