抗急非淋M_2和M_5型白血病单抗对骨髓粒-单核细胞集落形成(CFU-GM)的影响  

Effect of the Monoclonal Antibody to Acute Non-lymphocytic Leukemia (type M_2 and M_5) on CFU-GM

作　　者：潘荆华[1] 鹿巍[1] 李秀芝[1] 吴铁楠[1] 王诚[1] 宋艳秋[2] 郝秀智[2] 刘晓玲[2] 李宏宾 

机构地区：[1]卫生部长春生物制品研究所,长春130062 [2]白求恩医科大学第一临床学院

出　　处：《中国生物制品学杂志》1993年第3期104-106,共3页Chinese Journal of Biologicals

摘　　要：为了使单抗用于骨髓净化和导向药物的研究,应用分泌抗急非淋M_2和M_5型单抗1D_1和1A_1,观察对正常骨髓粒-单核细胞集落形成单位(CFU-GM)的影响。结果实验组与对照组比较无显著性差异,说明单抗对CFU-GM没有影响,不损伤正常骨髓造血干细胞,为M_2和M_5型单抗用于骨髓净化和导向药物的研究提供实验依据。In order to use McAb for the purification of bone marrow and study of missile drug, the effect of monoclonal antibody to acute non-lymphocytic leukemia (type M_2 and M_5) on CFU-GM was observed using cell strains 1D_1 and 1A_1, which could secrete monoclonal antibody to acute non- lymphocytic leukemia type M_2 and type M_5 respectively. No significant difference was found between the results observed in trial group and control group. It suggested that McAbs had no effect on CFU- GM could not damage normal bone marrow hemopoietic stem cells. The result provided basis for purification of bone marrow and study of missile drug.

关 键 词：单克隆抗体 白血病 细胞集落 

分 类 号：R392-33[医药卫生—免疫学]