妊娠肝内胆汁郁积症47例临床分析  

Intrahepatic cholestasis during pregnancy:Clinical analysis of 47 cases.

作　　者：吴元赭[1] 陆康民[1] 苏延华[1] 

机构地区：[1]南京军区南京总医院妇产科,210002

出　　处：《中国实用妇科与产科杂志》1993年第5期281-282,共2页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：血清胆酸显著升高是妊娠肝内胆汁郁积症的一项特征性指标。应用放免分析法测定47例患者的血清结合胆酸,平均20.58±11.32μmol/L,较对照组增加8.3～144.8倍。按胆酸低、中、高分为三组,分别与临床症状、肝功能、分娩方式和妊娠结局进行比较,发现高胆酸组病情重、发病早和分娩并发症多。说明测定血清胆酸对诊断本病、判断病情及预后和及时处理具有重要的参考价值。It has been suggested that the significant increase of serum cholic acid is a typical sign of intrahepatic cholestasis during pregnancy (ICP). The concentration of serum cholic acid was measured by radioimmunoassay in 17 healthy women and 47 patients with ICP. In patients with intrahepstic cholestasis, the serum cholic acid concentration was 8.3 to 144.8 times that of healthy pregnant women. These patients were divided into three proups according to the level of serum cholic acid. A comparative analysis revealed that the level of cholic acid was strongly associated with abnormalities of some conventional liver unction tests,clinical manifestation, delivery pattern and outcome in the patients with ICP. All of these suggested that the serum cholic acid assay was very important and sensitive for the diagnosis, prognosis and timely management in the patients with intrahepatic cholestasis during pregnancy.

关 键 词：妊娠 肝内 胆汁郁积 胆酸 

分 类 号：R714.255[医药卫生—妇产科学]