津白_3侏儒小鼠垂体前叶TSH细胞的免疫细胞化学观察  

Immunocytochemical Study on TSH Cells in the Anterior Pituitary of TA_3 Dwarf Mice

作　　者：刘皓[1] 曾孝儒[1] 陈芷沅[2] 陈雪娴[1] 刘金宝[1] 

机构地区：[1]天津医科大学组织胚胎学教研室,天津300070 [2]天津医科大学生物教研室

出　　处：《中国实验动物学杂志》2001年第3期146-148,共3页Chinese Journal of Laboratory Animal Science

摘　　要：目的　对津白3侏儒小鼠 (dWt)垂体前叶TSH细胞进行观察 ,以探讨dWt 是否存在垂体发育缺陷。方法　本实验应用免疫细胞化学技术和体视学原理进行定量分析。结果　dwt TSH细胞的体积密度 (Vv)和数密度(Nv)值均低于正常对照组。结论　dwt 由于垂体前叶TSH细胞数量减少 。Objective To research whether th ere were developmental defects in the anterior pituitary of Tianjin Albino 3 dwa rf mi ce (dw t). Methods In this study immunocytochemical and ster eological methods were employed.ResultsThe volumetric den sity (Vv) and numerical density (Nv) of the TSH immunoreactive cells were reduce d in both male and female dw t mice as compared with those in the normal contro l mice.ConclusionIt is suggested that the number decrease of the TSH cells in dw t mice leads to the deficiency of TSH secretion.

关 键 词：TSH 垂体前叶 小鼠 观察 免疫细胞化学技术 对照组 正常 侏儒 发育 细胞数量 

分 类 号：Q594.55[生物学—生物化学] R581[医药卫生—内分泌]