国产卡别多巴并用左旋多巴治疗125例震颤麻痹的临床观察  

CLINICAL RESPONSES OF DOMESTIC TABLETS OF LEVODOPA WITH CARBIDOPA IN TREATMENT OF 125 PARKINSONIANS

作　　者：张新根[1] 吴永麟[1] 曹慧兮[2] 谢晶[2] 郭明光[2] 余慧贞[3] 汤克俭[3] 王增[3] 陈生弟[4] 黄坚[4] 李舰南[4] 吴萍嘉[4] 朱培荣[5] 邵殿月[5] 

机构地区：[1]上海医科大学华山医院神经内科,200040 [2]上海第二医科大学仁济医院 [3]上海第二医科大学瑞金医院 [4]第二军医大学长征医院 [5]上海华东医院

出　　处：《中国新药杂志》1993年第3期48-51,共4页Chinese Journal of New Drugs

摘　　要：用国产“卡别多巴加左旋多巴”片治疗125例原发性震颤麻痹患者,其中未用过多巴类药物治疗者48例,有效39例(81.25%)。已用左旋多巴治疗者20例,改用本品后症状有进一步改善者19例(95%),疗效进步率平均提高33.75%,左旋多巴用量平均减少54.84%。已用 Madopar 治疗者55例,改用本品后症状有进一步改善者37例(67.28%),疗效进步率平均提高23.56%。已用 sinemet 治疗的2例,改用本品相似剂量治疗,取得相似疗效。副反应表现为胃肠道与心血管症状、中枢神经系统有不自主运动12例,开-关现象2例,精神症状2例。125 patients with primary paralysis agitans were treated with do-mestic tablets of levodopa with carbidopa.After the therapy,39 of the 48 patients forwhom this kind of drug have never been acepted before were improved with an effectiverate of 81.25%;20 patients for whom levodopa therapy have already been adopted gotfurther symptomatic relief in 19 cases;55 patients who were transferred from madoparto this tablets,got furtber symptomatic improvment in 37 cases;and 2 patients whowere transferred from sinemet to this drug,got a similar response as those of sinemet.Some gastro-intestinal,cardiovascular,central nervous(14 cases)and psychiatric(2cases)adverse drug reactions have been observed.

关 键 词：卡别多巴 左旋多巴 震颤麻痹 

分 类 号：R971.5[医药卫生—药品]