中小学生HBV感染状况调查及痘苗重组DNA乙肝疫苗免疫效果初步观察  

Studies on HBV Infection end Effect of Hepatitis B Vaccination with Recombinant Vaccinia Virus among Middle School Students and Pupils

作　　者：周玲[1] 钮菊英[1] 沈洪兵[1] 戴汉民 韩亚茹 王淑珍[2] 李津[2] 巩志立[2] 黄云霞[3] 马毅芬 唐红 陈永勤[3] 

机构地区：[1]南京医学院,210029 [2]卫生部北京生物制品研究所 [3]南京市玄武区卫生防疫站

出　　处：《中国学校卫生》1993年第3期157-158,共2页Chinese Journal of School Health

摘　　要：1991年6月对808名中小学生进行HBV标志血清学检查,HBsAg阳性率4.33%;抗-HBs阳性率25.37%;抗-HBc阳性率33.91%;HBV感染率40.84%。HBV感染者中抗-HBc阳性比例最高(83.94%),其次抗-HBs,单测HBsAg仅能发现10.61%的HBV感染者。HBV感染者中单项抗-HBs阳性占15%,其中59.18%达到保护水平。对223名乙肝易感者接种痘苗重组DNA乙肝疫苗,首针免疫后一个月抗-HBs阳转率达到46.64%;首针免疫后三个月抗-HBs阳转率达到98.65%。Blood specimens from 808 middle school students and pupils were detected for HBV-M in June, 1991. The infection rate was 40. 84%. The positivity rates of HBsAg,anti-HBs and anti-HBc were 4.33% ,25.37% and 33.94% ,respectively. Of 330 HBV infected subjects,83.94% were anti-HBc positive,while 10.61% HBsAg positive, when anti-HBc and anti-HBs were detected in combination, 99.39% of HBV infected subjects were found. Among 49 anti-HBs positive subjects, 59.18% effected autoimmune protection. Recombinant vaccinia virus prepared in Beijing was applied to immunize 223 HBV-M negative subjects. Seroconvertion rates of anti-HBs in vaccinated subjects were 46.64% and 98.65% for one and three months after the initial vaccination.

关 键 词：感染率 DNA 乙型肝炎 疫苗 阳转率 

分 类 号：R512.610.3[医药卫生—内科学]