延胡索乙素对离体大鼠胃酸分泌的抑制作用  

Inhibitory action of dl-tetrahydropalmatine on gastric acid secretion in vitro

作　　者：李毓[1] 王建华[1] 劳绍贤[1] 陈蔚文[1] 

机构地区：[1]广州中医学院脾胃研究室,广州510407

出　　处：《中国药理学通报》1993年第1期44-47,共4页Chinese Pharmacological Bulletin

摘　　要：探讨延胡素乙素(dl—THP)对离体大鼠胃粘膜和胃壁细胞泌酸功能的影响.结果:dl—THP明显抑制胃粘膜基础胃酸分泌.但洗脱药物1.5～2h后其作用即显著减弱.对于组胺(His)诱导的胃粘膜及壁细胞泌酸、dl—THP均使His的量效曲线非平行右移.并抑制最大泌酸反应;pD_z^1值分别是4.72和4.70。The action of dl - tetrahydropal-matine(dl-THP) was studied in two preparations in vitro : the isolated rat gastric mucosa and parietal cells, dl-THP was found to inhibit significantly basal acid formation by the gastric mucosa in a dose - response fashion. The effect was reversible, acid secretion returning to control levels 1. 5~2h after the preparation underwent a double wash, dl - THP also produced a significant and dose - dependent inhibition of histamine - induced secretion in the gastric mucosa and parietal cells, shifted the histamine dose -response cuver to the right and suppressed the maximum acid production, with pD_2~1 values of 4. 72 and 4. 70, respectively.

关 键 词：延胡索乙索 胃酸分泌 胃粘膜 大鼠 

分 类 号：R965.2[医药卫生—药理学]