赛拉嗪对小鼠胃肠运动及大鼠胃肠电的影响  

The influences of xylazine on the gastrointestinal motility in mice and on the gastrointestinal electrical rhythm in rats

作　　者：明亮[1] 许冠荪[2] 王瑜[1] 刘维州[2] 王永祥[1] 张群群[2] 章家胜[1] 王洪光[1] 徐叔云[1] 

机构地区：[1]安徽医科大学药理教研室,合肥230032 [2]安徽中医学院经络研究所,合肥230038

出　　处：《中国药理学通报》1993年第2期125-128,共4页Chinese Pharmacological Bulletin

摘　　要：育亨宾(0.5～4mg·kg^(-1),sc)和苯口恶咪唑(2～8 mg·kg^(-1).sc)剂量依赖性地拮抗赛拉嗪(4mg·kg^(-1),sc)对小鼠胃肠推进运动的抑制作用.赛拉嗪(2、4 mg·kg^(-1),sc)可乐定(120μg·kg^(-1),sc)抑制大鼠胃、十二指肠、空肠、回肠的肌电活动,用药后30min作用最显著。育亨宾(4 mg·kg^(-1),sc)一定程度地拮抗赛拉嗪(4 mg·kg^(-1),sc)抑制胃肠肌电活动的作用.Yohimbine (0. 5~4mg · kg-1, sc) and idazoxan (2~8 mg · kg-1,sc) showed a dose related antagonistic action on the inhibitory effect of xylazine (4mg · kg-1,sc) on the gastrointestinal propulsive motility in mice. Xylazine (2mg,4mg · kg-1,sc),clonidine(120 μg · kg-1,sc) exhibited the inhibitory effect of gastrointestinal basic electrical rhythm on the stomach, duodenum, jejunum and ileum in rats. The inhibitory effects of these drugs were the strongest at 30 min after administration of Compounds. Yohimibine (4mg · kg-1,sc) was found to antagonize the inhibitory effect of xylazine (4mg · kg-1,sc) on the gastrointestinal basic electrical Rhythm.

关 键 词：赛拉嗪 育亨宾 胃肠促进剂 

分 类 号：R965[医药卫生—药理学]