曲尼司特对豚鼠肺组织β肾上腺素受体向下调节的影响  

The effect of tranilast on the down-regulation of beta-adrenoceptors

作　　者：杨玉[1] 殷凯生[1] 杨明[1] 

机构地区：[1]南京医学院第一附属医院呼吸科,江苏210029

出　　处：《中国药理学通报》1993年第2期114-117,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目

摘　　要：用放射配体结合分析法分别测定了正常组、特布他林组、特布他林十曲尼司特组豚鼠的肺组织β受体最大结合力和解离常数,结果显示:给特布他林后豚鼠肺组织β受体发生明显的向下调节.曲尼司特可预防此向下调节的发生.The effect of tranilast on the down- regulation of beta- adrenoceptor agonist was investigated. Male guinea pigs were divided into 3 groups, one group is control. Others were received injection of terbutaline or terbutaline plus tranilast for successive 5 days. The radioli-gand binding assays for beta-adrenoceptors in the lung membranes of the guinea pigs were per- formed. The results showed the numbers of maximal binding sites (Bmax) of beta-adrenoceptors in terbutaline group was significantly less than that in control group ( P<0. 01). There was no significant difference in Bmax between control group and terbutaline plus tranilast group ( P> 0. 05).The affinity ( Kd) of beta-adrenoceptors both in terbutaline group and in terbutaline plus tranilast group was higher than that in control (P<0. 01). The differences of Kd of beta-a-drenoceptors between terbutaline group and terbutaline plus tranilast group were not significant. Tranilast partially prevented the down- regulation of beta adrenoceptors caused by terbutaline.

关 键 词：曲尼司特 特布他林 哮喘 

分 类 号：R974.3[医药卫生—药品]