喹啉酸诱发实验性癫痫作用机制的初步研究  

A preliminary study on mechanism of experimental epilepsy induced by icv quinolinic acid in mice

作　　者：陶成[1] 孙奥丽[2] 王年生 周向方 

机构地区：[1]北京医科大学药理教研室,北京100083 [2]山东省淄博市第二卫生学校,255015 [3]中国药物依赖性研究所,北京100083

出　　处：《中国药理学通报》1993年第2期118-121,共4页Chinese Pharmacological Bulletin

摘　　要：喹啉酸是一种内源性的兴奋性氨基酸,给小鼠每只icv10μl(1g·L^(-1)),可引起典型的实验性癫痫。ip异鹅羔胺激动GABA_A型受体;或ip GABA降解酶抑制剂氨氧乙酸,从而增加CNS中的GABA含量;或ip甲基三唑安定以增强GABA受体的亲和力来高脑中GABA能神经系统的功能,均能减弱或对抗喹啉酸的致惊作用。相反,sc GABA_A型受体拮抗剂荷包牡丹碱;或sc GABA合成和释放抑制剂3-巯基丙酸来降低中枢GABA能神经系统的功能,则能促进喹啉酸的致惊作用.所有这些结果提示.CNS中GABA系统的功能在喹啉酸的致惊机制中可能起调控作用。The effect of GABA ergic system in the brain in mediating convulsions induced by quinolinic acid (QA) was studied. Muscimol,an agonist of GABAA-receptor, and aminooxyacetic acid (AOAA),an inhibitor of GABA transami-nase(GABA-T) ,and alprazolam which increased the affinity of GABA-receptor as it binds with benzodiazepine-receptor, were used to increase GABAergic function in the brain. Results showed that the above substances antagonized QA-induced convulsions. In contrast, bicu- culline,an antagonist of GABAA-receptor, and 3-mercaptopropionic acid (3-MP), an inhibitor of both GABA synthesis and its release, were used to decrease GABA ergic function in the CNS. They were found to potentiate QA-induced seizures. All these results suggest that GABA ergic system in brain plays an important role in modulating QA-induced convulsions.

关 键 词：喹啉酸 癫痫 

分 类 号：R562.250.2[医药卫生—呼吸系统]