法莫替丁、雷尼替丁、西米替丁的药理作用比较  

Comparative studies of pharmacologic effects between Famotidine, Ranitidine and Cimetidine

作　　者：李新芳[1] 吕金胜[1] 黄钺华[1] 

机构地区：[1]第三军医大学药理教研室

出　　处：《中国药理学通报》1993年第3期213-217,共5页Chinese Pharmacological Bulletin

摘　　要：Fam非竞争性地拮抗组胺对豚鼠心房和大鼠于官的作用.而Ran和Cim呈竞争性地拮抗作用。它们的pA_z值分别是6.24和8.26.5.16和7.22.4.08和6.17。Fam、Ran、Cim均呈剂量依赖性的减少大鼠基础胃酸和胃蛋白酶分泌,抑制组胺刺激性胃酸分泌.预防应激及消炎痛和组胺引起的急性胃粘膜损伤.促进醋酸所致的慢性胃溃疡的愈合.F am的作用强度为Ran的6～8 倍.Cim的30～40倍.此外Cim能明显增加戊巴比妥的催眠作用,Fam的作用弱于Cim·而Ran没有作用。Famotidine ( Fam ) antagonized the effects of histamine on guinea pig atria and rat uteri MI vitro non-competitively,however the antagonisms of Ranitidine(Ran) and Cimetidine (Cim ) on hoistamine were competitive, their pA2 were 6. 24, 5. 16 and 4. 08 for guinea pig atria , 8. 26, 7. 22 and 6. 17 for rat uteri respectively. They reduced gastric secretion of acid and pepsin of pylorus ligated rats in dose-related manner, inhibited gastric secretion stimulated by histamine, prevented the acute gastric lesion from stress, indomethacin and histamine, and enhanced the healing process of chronic gastirc ulcerinduced by acetic acid in rats. Moreover, Fam was much more potent than Ran (6~8 times) and Cim(30 - 40 times). Besides,Cim increased hypnotic effect of phenobartal, but Ran and Fam had no or Ittile such effects.

关 键 词：法莫替丁 雷尼替丁 胃溃疡 

分 类 号：R975.6[医药卫生—药品]