甘草类黄酮对乙醇所致小鼠肝脏损伤的影响  

Effects of flavonoids of glycyrrhiza on ethanol-induced liver injury in mice

作　　者：王根生[1] 韩哲武[1] 

机构地区：[1]内蒙古医学院药理教研室

出　　处：《中国药理学通报》1993年第4期271-273,共3页Chinese Pharmacological Bulletin

摘　　要：小鼠预先以甘草类黄酮(FG)ig,无论给药1 次或给药4次均可抑制乙醇诱导的小鼠肝脏丙二醛含量的增加和还原性谷胱甘肽的耗竭,其作用呈剂量依赖性.电镜检查证实fG可保护乙醇所致的肝细胞超微结构的损伤.但乙醇灌胃后再用FG,未见保护作用。The effect of Flavonoids of Gly-cyrrhiza (FG) on ethanol-induced liver injury was studied in mice. Administration of FG to mice prior to ethanol treatment ,either once daily for four days or a single dose, the increase of malondialdehyde and the decrease of reduced glutathione were inhibited dose- dependently. Electron microscopic examination showed that the ethanol-induced damage of hepatocytes could be ameliorated by FG pretreatment. However, no protective effect was observed when FG was administrated to mice after ethanol intoxication.

关 键 词：甘草类黄酮 乙醇 肝损伤 

分 类 号：R965.2[医药卫生—药理学]