四氢巴马汀抗缺血再灌注心律失常的作用及其机理  

Protective effect of dl-tetrahydropalmatine on cardiac arrhythmias induced by reperfusion of ischemic myocardium

作　　者：汪永孝[1] 郑云敏 谭月华[1] 

机构地区：[1]第四军医大学药理教研室,西安710032 [2]第四军医大学空医系,西安710032

出　　处：《中国药理学通报》1993年第5期358-361,共4页Chinese Pharmacological Bulletin

摘　　要：四氢巴马汀(THP)5～15mg·kg^(-1)iv明显降低大鼠心肌缺血再灌注心律失常的发生率和心肌脂质过氧化物的含量。THP1、3和10μmol·L^(-1)使大鼠离体心室肌去氧肾上腺素量效曲线非平行性右移.最大反应压低,表现为非竞争性拮抗作用。THP10μmol·L^(-1)能显著抑制缺氧再给氧所致豚鼠离体心室肌的迟后除极和触发活动。表明THP有良好的抗缺血再灌注心律失常的作用.其机理是阻止氧自由基的损害作用和迟后除极的产生.而与心肌α_1受体可能无关。Dl-tetrahydropalmatine (THP) 5 ~ 15 mg · kg-1 iv markedly reduced the incidences of cardiac arrhythmias and myocardial lipidperoxide content after reperfusion of the is-chemic myocardium in rats. In isolated rat ventricular muscles, THP 1,3 and 10 μmol·L-1 shifted the concentration-effect curves for phenylephrine to the right unparally, together with decreasing their maximal responses,exhibiting a non-competed antagonistic action. It was also found that THP 10 μmol·L-1was able to reduce the amplitude of delayed afterdepolar-izations and to stop triggered activity and/or ab- normal automatic activity induced by reoxygena-tion of hypoxic myocardium in isolated ventricular muscles of guinea pig. These results suggest that the protective effects of THP might be attributed, at least in part, to the depression of delayed afterdepolarizations and the prevention of oxygen free radical injury without the involvement of the cardiac α1-adrenoceptors.

关 键 词：四氢巴马汀 再灌注 抗心律失常药 

分 类 号：R972.2[医药卫生—药品]