奎尼丁和西米替丁的抗心律失常与抗脂质过氧化作用  

Anti-arrhythmia and anti-lipid peroxidation effect of Quinidine and Cimetidine

作　　者：景有伶[1] 郑俊国[1] 杨秋[1] 宋桂兰[1] 石磊[2] 陈春林[2] 付定一[2] 

机构地区：[1]华北煤炭医学院病生教研室,唐山063000 [2]华北煤炭医学院药理教研室,唐山063000

出　　处：《中国药理学通报》1993年第5期362-364,共3页Chinese Pharmacological Bulletin

摘　　要：测定肾上腺素(Adr)诱发家兔心律失常后血浆及组织匀浆中脂质过氧化物代谢产物丙二醛的含量变化。发现血浆及组织匀浆中MDA含量明显增加,奎尼丁(Qui)6 mg·kg^(-1),iv,西米替丁(Cim)37.5mg·kg^(-1),iv,及两药剂量减半后合用均能有效地防上Adr诱发的定性心律失常,并能显著抑制MDA的生成,但以合用组效果更显著。The content of malondialdehyde (MDA) , a metabolite of lipid peroxide (LPO) , in plasma and tissue homongenate from rabbits with arrhythmias induced by adrenaline (Adr) was determined. The results showed that the MDA level was increased in plasma and tissue homogenate. Quinidine (Qui) 6 mg · kg-1, Cimetidine (Cim) 37. 5 mg·kg-1, and 1/2 dose of both drugs administered intravenously could significantly prevent ventricular arrhythmias induced by Adr and inhibit the production of MDA. The findings suggest that the effect of Qui and Cim on arrhythmias induced by Adr may associate with its inhibition on lipid peroxi-dation.

关 键 词：奎尼丁 西米替丁 抗心律失常药 

分 类 号：R972.2[医药卫生—药品]