肽6A对大鼠异丙肾上腺素心肌损伤的治疗作用  

The protective effect of peptide 6A on isoproterenol-induced myocardial damage in rat

作　　者：姚兴海[1] 李辉[1] 付爱华[1] 汤健[1] 唐朝枢[1] 赵明[2] 彭师奇[2] 张晓明[3] 王秉瑞[4] 吴祥林[4] 

机构地区：[1]北京医科大学心肺内分泌研究室,100083 [2]北京医科大学天然药物与仿生药物国家重点实验室,100083 [3]首钢总医院检验科,北京100730 [4]卫生部兰州生物制品研究所,兰州730000

出　　处：《中国药理学通报》1993年第5期373-374,378,共3页Chinese Pharmacological Bulletin

摘　　要：给大鼠异丙肾上腺素(30 mg·kg^(-1).d^(-1)·sc)造成心肌损伤的模型上.用合成的纤维蛋白原降解肽片断——肽6A(50μmol·kg^(-1)·d^(-1))治疗.可明显减轻由异丙肾上腺素引起的心肌损伤.抑制心肌肌酸磷酸激酶、α-羟丁酸脱氢酶、乳酸脱氢酶和谷草转氨酶的漏出.降低血浆纤维蛋白原的含量.阻止异丙肾上腺素引起的心肌组织钙聚积.表现了明显的心肌保护作用。提示肽6A可能对于缺血性心脏疾病的治疗具有潜在临床应用价值。Cardio-protective action of synthetic peptide 6A, fibrinogen degradation segment, was observed on the myocardial injury model produced by subcutaneous injection of iso-proterenol (30 mg·kg-1-d-1) into rat. Treatment with peptide 6A (50 μmol·kg-1· d-1,iv) significantly ameliorated isoproterenol-induced myocardial lesion, inhibited release of myocardial creatine phosphokinase, α-hydroxybutyrate dehydrogenase, lactate dehydrogenase and gluta-mate-oxaloacetate transaminase, lowered plasma fibrinogen content,and markedly prevented myocardial calcium accumulation. The results suggest that peptide 6A could have potential significance for clinical therapy of ischemia heart diseases.

关 键 词：肽6A 异丙肾上腺素 心肌损伤 

分 类 号：R965.1[医药卫生—药理学]