动脉粥样硬化的实验研究 Ⅳ动脉粥样硬化家兔主动脉平滑肌细胞增殖和血小板胞浆游离钙水平的改变  

Experimental study of atherosclerosis ⅣChanges of aortic smooth cell proliferation, platelet free calcium and aggregation in atherosclerotic rabbits and the effects of 8501 on these changes.

作　　者：汪钟[1] 胡艳华[1] 朱国强 

机构地区：[1]中国医学科学院基础医学研究所药理教研室,北京100005

出　　处：《中国药理学通报》1993年第5期346-349,共4页Chinese Pharmacological Bulletin

摘　　要：探讨动脉粥样硬化家兔主动脉平滑肌细胞增殖与血小板胞浆游离钙水平、血小板聚集性变化的关系。发现高脂血症家兔主动脉平滑肌细胞较正常平滑肌细胞增殖明显增强.经高脂血清孵育的平滑肌细胞增殖增强。此外高血脂动物的血小板胞浆游离钙水平与聚集性也增强.提示高脂血清及血小板释放PDGF增多可能是刺激平滑肌细胞增殖的原”因。用具有降脂作用的中药有效成分8501处理的家兔主动脉平滑肌细胞和用8501处理的家兔血清孵育后的平滑肌细胞的增殖明显减低.这也许与8501对TXA_2/PGI_2平衡调节有关。Smooth muscle cell (SMC) proliferation, platelet free calcium level and aggregation of experimental atherosclerotic rabbits were investigated in this study. Aortic SMC ofhyperlipidemic rabbits in vitro showed higher growth activity than did normal rabbit SMC. And also hyperlipidemic serum stimulated SMC to proliferate at a significantly greater rate than control serum. Moreover, the level of platelet free calcium and the platelet aggregation was also higher in hyperlipidemic rabbits, indicating that activitated platelets possibly release more PDGF to act as a stimulator to SMC proliferation and calcium is an important factor to activate platelets. Furthermore, SMC from 8501-treated rabbits appeared lower proliferative rate than thecells from hyperlipidemic rabbits. And serum from those rabbits inhibited SMC proliferation compared with hyperlipidemic serum, the inhibitory effect was even stronger than that of normal serum. It may be relevant to the favorable effects of 8501 to TXA2/PGI2 balance.

关 键 词：动脉粥样硬化 主动脉 平滑肌细胞 

分 类 号：R543.5[医药卫生—心血管疾病]