淫羊藿多糖和甙的胸腺免疫药理作用  

Immunopharmacologic effects of Epimedium Polysaccharide and Icarrin on mouse thymus

作　　者：丁雁[1] 邢善田[2] 周金黄[2] 

机构地区：[1]江苏省常州市第一人民医院,常州213003 [2]军事医学科学院毒物药物研究所,北京100850

出　　处：《中国药理学通报》1993年第5期342-345,共4页Chinese Pharmacological Bulletin

摘　　要：给小鼠sc淫羊藿多糖(EPS)和甙(Icarrin).对二者的胸腺免疫药理作用进行研究,结果发现:胸腺细胞产生IL-2和~3H-TdR的掺入能力增强。EPS使胸腺内L_3T_4^+和Lyt_z细胞数目减少.伴同胸腺细胞对ConA刺激的增殖反应降低。Icarrin对胸腺内上述两个细胞亚群无影响,但使胸腺细胞对ConA刺激的反应增高。故认为EPS和Icarrin对胸腺都有免疫激活作用。EPS可能有促进胸腺释放成熟细胞的作用。In this paper we report im-munopharmacologic effects of Epimedium Polysaccharide (EPS) and Icarrin on mouse thy-mus. It was found that EPS or Icarrin administered subcutaneously in mouse had following effects: (1)EPS enhanced the proliferation and IL-2 production of thymocytes, and decreased the L3T4 and Lyt2 cell numbers and responses to Con A stimulation of the thymus; (2) Icarrin increased response to ConA stimulation to mouse thymus cell. These results suggest that both EPS and Icarrin have immunes stimulating effect on thymus. EPS possibly promoted the migration of thymocytes from the thymus to peripheral organs.

关 键 词：淫羊藿多糖 淫羊藿甙 胸腺 免疫 

分 类 号：R967[医药卫生—药理学]