钾通道阻滞剂及毒毛花甙G对依血管内皮舒张作用的影响  

Effects of K^+channel blockers and strophantin G on endothelium-dependent relaxation

作　　者：刘确[1] 胡文淑[1] 

机构地区：[1]同济医科大学药理教研室,武汉430030

出　　处：《中国药理学与毒理学杂志》1993年第1期39-41,共3页Chinese Journal of Pharmacology and Toxicology

摘　　要：四乙铵(TEA),Ba^(2+),格列本脲(可阻滞ATP敏感K^+通道)及毒毛花甙G均显著抑制Ach诱发的兔主动脉环依内皮舒血管效应.cromakalim的舒血管作用是不依赖内皮的,且为上述药物所抑制,本实验结果提示离体兔主动脉环上ACh诱发的依内皮舒张中,可能有ATP敏感的K^+通道及Na^-—K^+泵参与.The effects of tetraethylamine(TEA),Ba2+,glibenclamide(Glib),strophantin G on the relaxation induced by acetylcholine(ACh)were studied in rabbit aortic rings precontracted by phenylephrine(1μmol·L-1).TEA(1-2μmol·L-1),Ba2+(50μmnol·.L-1),Glib(50μmol·L-1)and strophantin G(5μmol·L-1)inhibited the relaxation induced by ACh.The vasodilator effect of cromakalim was endothelium-independent and inhibited by TEA(2-4 mmol·L-1),Ba2+(50μmol·L-1),strophantin G(10μmol·L-1).These results suggest that ATP-sensi-tive K+channel and Na+-K+pump could be,at least partially,responsible for the endothelium-dependent relaxation induced by ACh.

关 键 词：血管 毒毛旋花子甙 钾通道阻滞剂 

分 类 号：R963[医药卫生—微生物与生化药学]