甲基黄酮醇胺对豚鼠心脏乳头状肌细胞异常自律性及收缩力的影响  

Effects of methylflavonolamine on abnormal automaticity and contractile force in guinea pig papillary muscles

作　　者：马季骅 张培华[1] 刘颖 顿文[2] 

机构地区：[1]武汉冶金医学高等专科学校生理教研室,武汉430080 [2]山西医学院药理教研室,太原030001

出　　处：《中国药理学与毒理学杂志》1993年第3期173-175,共3页Chinese Journal of Pharmacology and Toxicology

摘　　要：本研究观察了甲基黄酮醇胺(MFA)对豚鼠心脏乳头状肌细胞异常自律性及收缩力的影响.5,10和15μmol·L^(-1)的MFA可剂量依赖性地抑制低K^+加去甲肾上腺素诱发的迟后去极化和触发激动,高K^+加异丙肾上腺素诱发的慢反应动作电位及收缩力以及钡离子诱发的自律性.结果提示MFA的作用可能与Ca^(2+)通道阻滞有关。The effects of methylflavonolamine(MFA)on abnormal automaticity and contractile force were observed in guinea pig papillary muscles.MFA 5,10 and 15μmol·L-1 suppressed the delayed afterdepolarization and triggered activity in guinea pig papillary muscles exposed to the Tyrode's solution containing 0.6 mmol·L-1 KC1 and 1μg·ml-1 norepinephrine,the contractile force and slow response action potential elicited by 1μmol·L-1 isoprenaline in guinea pig papillary muscles perfused with 25mmol·L-1 KC1 Tyrode's solution,and the abnormal automaticity elicited by Ba2+(4 mmol·L-1)in a dose-dependent manner.The results suggest that MFA may have an inhibitory effect on the inward Ca2+current of the myocardium.

关 键 词：甲基黄酮醇胺 乳头状肌 动作电位 

分 类 号：R331.31[医药卫生—人体生理学]