钌红对豚鼠离体心室肌细胞钙激活电流的影响  

Effects of ruthenium red on Ca^(2+)-activated current in isolated guinea pig ventricular myocytes

作　　者：崔毅[1] 谭月华[1] 

机构地区：[1]第四军医大学药理教研室,西安710032

出　　处：《中国药理学与毒理学杂志》1993年第3期235-236,共2页Chinese Journal of Pharmacology and Toxicology

摘　　要：钌红(ruthenium red,RR)是电镜研究中常用的一种组织染料。近来发现RR具有抑制线粒体钙摄取和肌质网钙释放等作用。但RR对心肌细胞内Ca^(2+)浓度的影响目前尚未见报道。本文通过观察RR对豚鼠离体心室肌细胞钙激活电流的影响,对这一问题作一探讨。Effects of ruthenium red(RR)on [Ca2+] in isolated guinea pig ventricular myocytes were investigated using Ca2+-activated current as an indicator of changes in [Ca2+] Action potentials were interrupted by the application of a 300 ms voltage clamp to 40 mV in order to elicit the Ca2+-activated current.Exposure to 2.5*****umol·L-1 RR resulted in an increase in Ca2+ activated current without changingaction potentials.RR appeared not to modify the time course of the envelope of currents.The results indicate that RR could increase [Ca2+] in guinea pig ventricular myocytes.

关 键 词：钌红 心肌细胞 钙 激活电流 

分 类 号：R965[医药卫生—药理学]