腹水铁蛋白、腺苷脱氨酶联合检测鉴别良、恶性腹水的临床意义  

Clinical Significance of Combined Determination of Ascites Ferritin and Adenosine Deaminase for Discrimination Between Malignant and Unmalignant Ascites

作　　者：赵金满[1] 沙文阁[1] 石田[2] 孙玉强[2] 

机构地区：[1]中国医科大学附属第一医院内科 [2]中国医科大学附属第一医院内科实验室

出　　处：《中国医科大学学报》1993年第4期272-274,共3页Journal of China Medical University

摘　　要：本文测定38例恶性腹水和31例良性腹水铁蛋白和腺苷脱氨酶(ADA)的浓度。结果:铁蛋白浓度在恶性腹水组(Ⅰ)为320.9±132.8μg/L,结核性腹膜炎腹水组(Ⅰ,n=11)为366.8±72.5μg/L,其它良性腹水组(Ⅱ,n=20)为118.2±72.8μg/L。Ⅰ组与Ⅱ组间差异无统计学意义(P>0.05),Ⅰ组与Ⅱ组间,Ⅰ组与Ⅱ组间差异均非常显著(P<0.01)。ADA浓度在Ⅰ组为21.26±7.33u/L,Ⅱ组为41.35±17.27u/L,Ⅱ组为16.48±4.47u/L。Ⅰ组与Ⅱ组间、Ⅱ组与Ⅲ组间差异均非常显著(P<0.01)。Ⅰ组与Ⅱ组间差异显著(P<0.05)。以腹水铁蛋白浓度230ug/L、ADA浓度30u/L作为良、恶性腹水分界值,铁蛋白敏感性为81.6%,特异性为61.3%.ADA敏感性为89.5%,特异性为29%。铁蛋白、ADA联合检测敏感性为73。7%,特异性为80.6%。揭示铁蛋白、ADA联合检测是鉴别良、恶性腹水有价值的指标。The concentrations of ascites ferritin and adenosine deaminase (ADA) were investigated in 38 patients with malignant ascites and 31 patients with unmalignant ascites. Ferritin concentration (x±s) was 320.9±132.8μg/L in malignant ascites (group Ⅰ), 366.8±72.5μg/L in tuberculosis peritonitis (n=11 ,group Ⅱ), 118.2±72.8μg/L in other unmalignant ascites (n=20 ,group Ⅲ). The concentration in group Ⅰ did not significantly different from group Ⅱ (P>0.05). The concentration was significantly higher in both group Ⅰ and group Ⅱ than in group Ⅲ (P<0.01). ADA concentration was 21.26±7.33u/L in group Ⅰ , 41.35±17.27u/L in group Ⅱ , 16.48±4.47u/L in group Ⅲ. The concentration was significantly higher in group Ⅱ than in both group Ⅰ and group Ⅲ (P<0.01), and the concentration was significantly higher in group Ⅰ than group Ⅲ (P<0.05). Our data suggested that combined determination of ferritin and ADA is a valuable indicator for discrimination between malignant and unmalignant ascites.

关 键 词：铁蛋白 腺苷脱氨酶 腹水 

分 类 号：R442.5[医药卫生—诊断学]