抗血吸虫药1-(5-硝基-2-噻吩亚甲氨基)咪唑烷-2-酮及其类似物的合成  

SYNTHESIS OF 1-(5-NITRO-2-THIENYLIDENEAMINO)-2-IMIDAZOLIDONE AND ITS ANALOGS AS SCHISTOSOMICIDES

作　　者：马桢[1] 黄兰荪 

机构地区：[1]中国预防医学科学院寄生虫病研究所,上海200025

出　　处：《中国医药工业杂志》1993年第4期156-159,共4页Chinese Journal of Pharmaceuticals

摘　　要：1-(5-硝基-2-噻吩亚甲氨基)-咪唑烷-2-酮(1)具有抗曼氏血吸虫作用。考虑其结构与硝唑咪相似,推测该化合物可能也具有抗日本血吸虫作用,故合成了该化合物及其类似物。药理筛选证明,1确有较显著的抗日本血吸虫作用。Effect of 1-(5-nitro-2-thienylideneamino)-2-imidazolidone(1)against Schistosoma mansoni in mice has been reported.Since the structure of 1 issimilar to that of niridazole possessing activity against S.japonicum in mice.1and its analogs were synthesized.Screening test showed that 1 had pronouncedactivity against S.japonicum in mice.

关 键 词：抗血吸虫药 咪唑烷二酮 合成 

分 类 号：R978.63[医药卫生—药品]