齐诺康唑及其类似物的合成与抗真菌活性  

SYNTHESIS AND ANTIFUNGAL ACTIVITY OF ZINOCONAZOLE AND ITS ANALOGUES

作　　者：贺全山 刘丽琳[2] 

机构地区：[1]南京军区军医学校,福州350003 [2]第二军医大学药学系,上海200433

出　　处：《中国医药工业杂志》1993年第4期153-156,共4页Chinese Journal of Pharmaceuticals

摘　　要：合成了口服抗真菌药齐诺康唑(E-851)及其两种类似物(E-852,E-853)。初步药敏试验表明,三种化合物的抑菌程度均比咪康唑强,而与酮康唑相似,尤以 E-852的效果更佳。Zinoconazole (E-851) and its two analogues (E-852 and E-853)were syntheized.The preliminary biological study showed that the inhibitory ef-fects of these compounds against pathogenic fungi were more potent than that ofmiconazole and similar to that of ketoconazole.E-852 has even better effects.

关 键 词：齐诺康唑 抗真菌 合成 抗真菌药 

分 类 号：R978.5[医药卫生—药品]