短期高胰岛素血症对脂肪细胞胰岛素受体结合和葡萄糖氧化的影响  

Effect of Short-term Experimental Hyperinsulinemia on Insulin Binding and Glucose Oxidation in Adipocytes

作　　者：康有厚 刘亚兵[2] 陈援朝[3] 姚文贞[2] 张世荣[2] 池芝盛[1] 

机构地区：[1]中国医学科学院 [2]中国科学院动物研究所 [3]北京军区总医院

出　　处：《中国医学科学院学报》1993年第5期380-384,共5页Acta Academiae Medicinae Sinicae

摘　　要：许多研究表明,高胰岛素血症和胰岛素抵抗是肥胖症、葡萄糖耐量低减和轻度非胰岛素依赖型糖尿病的显著特征,而胰岛素抵抗可能又继发于高胰岛素血症。有的作者发现,在长期用胰岛素治疗的胰岛素依赖型糖尿病患者中,许多人也有高胰岛素血症和胰岛素抵抗,故高胰岛素血症可能也是此类患者发生胰岛素抵抗的因素之一。为更清楚地观察高胰岛素血症单一因素对靶细胞胰岛素作用的影响,本研究给正常大鼠皮下注射胰岛素使其产生高胰岛素血症,然后测定大鼠脂肪细胞膜特异结合胰岛素百分率和脂肪细胞葡萄糖氧化。To investigate the effect of hyperinsulinemia on insulin action in target cells, insulin binding to adipocyte membranes and glucose oxidation in adipose cells were mearsured in control and experimentally hyperinsulinemic rats. The results showed that: 1) body weight, food intake and adipocyte diameter were not significantly changed, but serum insulin was significantly increased and blood glucose was markedly decreased in hyperinsulinemic rats as compared to control; 2) adipocyte membranes from hyperinsulinemic rats bound significantly less insulin than those from control rats, with a decreased number of insulin receptors and unchanged affinity of receptors for insulin; 3) significantly increased basal (in absence of added insulin) and insulin stimulated glucose oxidation was found in hyperinsulinemic rats as compared with control. The data suggest that experimental hyperinsulinemia resulted in decreased num bers of insulin receptors but increased responsiveness to insulin in target cells.

关 键 词：高胰岛素血症 葡萄糖氧化 

分 类 号：R587[医药卫生—内分泌]