依托泊甙复乳处方设计和稳定性考核  

STUDY ON FORMULATION AND STABILITY OF MULTIPLE EMULSION CONTAINING ETOPOSIDE

作　　者：马晋隆[1] 陶涛[1] 熊全美[1] 陈瑞珠[1] 

机构地区：[1]上海医药工业研究院,上海200437

出　　处：《中国医药工业杂志》1993年第2期62-65,共4页Chinese Journal of Pharmaceuticals

摘　　要：通过对油的品种、乳化剂及 HLB 值、稳定剂等辅料的筛选,并经正交设计试验获得较稳定的 W_1o/w_2型依托泊甙复乳处方和制备工艺条件,测定了药物包裹率并考核了稳定性。Multiple emulsion (w/o/w) containing etoposide was formulatedby orthogonal design to screen oils,emulsifiers (and HLB Value),stabilizers.Its drug inclusion rate,leakage rate and particle size were determined.Theresults showed that the multiple emulsion has good stability.

关 键 词：依托泊甙 复乳 稳定性 抗癌药 

分 类 号：R979.1[医药卫生—药品]