DA-201树脂与XAD-8树脂纯化甘草酸效果的HPLC考察  

COMPARISON OF EFFICIENCY OF PURIFICATION OF GLYCYRRHIZIC ACID WITH DA-201 AND XAD-8 RESINS BY HPLC

作　　者：梁贵键[1] 张福成[1] 魏宁[1] 姚德佳[1] 黄进[1] 

机构地区：[1]中国人民解放军空军总医院,北京100036

出　　处：《中国医药工业杂志》1993年第8期339-343,共5页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金资助项目 No.29205037

摘　　要：以 HPLC 为检测手段,比较了 DA-201(国产)与 Amberlite XAD-8(美国)大孔吸附树脂在纯化甘草酸方面的效果,结果表明 DA-201优于 Amberlite XAD-8。并采用 DA-201树脂,对从甘草浸膏制备甘草酸新工艺进行了优化研究。二次过柱洗脱物甘草酸含量可达75%左右,回收率在66%以上。新工艺的产品含量和收率较目前的生产方法高。By means of HPLC,comparison of the efficiency of purificationof glycyrrizic acid (GA)with domestic DA-201 resin,and Amberlite XAD-8resin was made.Parallel control tests showed that DA-201 resin was superior toXAD-8.The new process of GA purification from glycyrrhiza extract by DA-201resin was optimized.The purity and recovery of GA in the second eluate wereabout 75% and 66%,respectively.This method gave higher purity and recoveryof GA than conventional ones.

关 键 词：甘草酸 高效液相色谱法 DA-201树脂 

分 类 号：TQ460.6[化学工程—制药化工]