柳氮磺吡啶栓治疗实验性溃疡性结肠炎的药效学研究  

PHARMACODYNAMIC INVESTIGATION OF SULFASALAZINE SUPPOSITORY IN EXPERIMENTAL ULCERATIVE COLITIS

作　　者：任晋斌 许卫红 马文运 刘志仁[2] 王晓竑 徐大毅[3] 耿引风[3] 

机构地区：[1]山西省药物研究所,太原030045 [2]山西职工医学院,太原030012 [3]山西医学院,太原030001

出　　处：《中国医药工业杂志》1993年第9期408-410,共3页Chinese Journal of Pharmaceuticals

摘　　要：柳氮磺吡啶(SASP)栓经直肠给药治疗大鼠溃疡性结肠炎3周,见结肠粘膜出血、糜烂溃疡病变点数较阴性对照组明显减少。病理检查见粘膜的弥漫性炎症消失或减轻,充血、水肿以及肠腺和固有膜间的炎细胞浸润消失或明显减轻。坏死的上皮和腺体以及糜烂溃疡面已修复,肠腺的杯状细胞显著增加。疗效优于同剂量灌胃给药。After sulfasalazine suppositories 2.0 or 1.0g/kg were administered to the rats with ulcerative colitis for 3 weeks, their macroscopic pathological changes decreased evidently in comparision with the control group. Histologically, it was seen that hyperemia, edema, inflammatory cell infiltration disappered or decreased evidently, tissue was repaired at the regions of erosion or ulcer, and goblet cells of gland increased in mucosa. The therapeutic effect of the suppository was superior to oral administration.

关 键 词：柳氮磺吡啶 溃疡性 结肠炎 栓剂 

分 类 号：R944.23[医药卫生—药剂学]