普萘洛尔对普罗帕酮的临床药物动力学影响  

Clinical Pharmacokinetics of Propafenoneg Combined with Propranolol in Patients with frequent Ventricular Premature Contractions

作　　者：史道华[1] 陈刚[1] 卓海通[1] 李剑春[1] 李露言[1] 吴振国[1] 

机构地区：[1]南京军区南京总医院,210002

出　　处：《中国医院药学杂志》1993年第2期51-52,共2页Chinese Journal of Hospital Pharmacy

摘　　要：频发性室性期前收缩(VPC_s)住院患者18例,随机分两组经先后单用及合用普罗帕酮(150mg,q8h)及普萘洛尔(20mg,q8h)至稳态后采样。普罗帕酮血药浓度—时间曲线均可用—室开放模型拟合。普罗帕酮单用时K,Cmax 及AUC 较两药合用时大(P<0.01),T_(1/2)、Vc/F 小(P<0.01,P<0.05)。本研究提示,为防止降低普罗帕酮治疗室性期前收缩的疗效,如两药必须合用时宜参考本提示并加强监护。Eighteen patients with frequent and complex ventricular premature contractions(VPCs)were divided into two groups.Propafenone(PPF,150mg q8h)and propranolol(PPL,20mg q8h)were used respectively and combined with each other.All the plasma concentration-time curves of PPF were fit one compartment model.The K,C_(max) and AUC of PPF used alonewere greaterP<0. 05,P<0.05)than that of both drugs used together.This study suggested that PPF was not suitable for com-bining with PPL because PPL could decrease PPF concentration and might lower the antiarrhythmic effect of PPF.

关 键 词：药物动力学 药物相互作用 

分 类 号：R969.2[医药卫生—药理学]