异烟肼透皮吸收的实验研究  

Studies on the transdemal assimilation of isoniazid

作　　者：于忠兴[1] 王岳祥[1] 

机构地区：[1]江苏省常州市第三人民医院,213001

出　　处：《中国医院药学杂志》1993年第4期163-165,共3页Chinese Journal of Hospital Pharmacy

摘　　要：本实验采用静态扩散装置,初步研究了异烟肼(Isoniazidum,INH)的透皮吸收情况,实验结果表明:INH 能透过离体的兔皮,且月桂氮(艹卓)酮(Iaurocapram,Azone.氮酮)能明显地促进其透皮吸收。含5%(V/V)Azone 的INH 供试液12h 后的透皮吸收率比不含Azone 者高50%。本文用抛物线拟合法建立了不同时间下不同浓度的Azone 对INH 透皮吸收率的数学模型,求得了Azone 对INH 透皮吸收促进作用的最佳浓度为5.4%。A static diffursion cell device was used for the preliminary investigation of the transdemal assimilation of isoniazid (INH).The results showed that INH could penetrate peeled rabbit skin and that azone could help the transdemal assimilation ofINH.The transdemal assimilation rate of INH containing 5% of azone was 50% higher than that without azone.It wascalculated by means of the parabola model that the best concentration of azone was 5.392%

关 键 词：异烟肼 氮酮 透皮吸收 

分 类 号：R978.3[医药卫生—药品]